期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 61, 期 24, 页码 11298-11308出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.8b01430
关键词
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资金
- National Key Research and Development Program of China [2018YFC0310903]
- National Natural Science Foundation of China (NSFC) [41676073, 81520108028]
- NSFC/CNRS joint project [81811530284]
- SKLDR/SIMM project [SIMM1705ZZ-01]
- Youth Innovation Promotion Association from Chinese Academy of Sciences [2016258]
- SA-SIBS Scholarship Program
A series of novel marine phidianidine derivatives were designed, synthesized, and evaluated for their immunosuppressive activities during our search of potential immunosuppressive agents with high efficacy and low toxicity from marine sources. These compounds were tested for their inhibitory activity on Con A induced T cell and lipopolysaccharide-induced B cell proliferation. Compounds 14a and 18c, displaying the most promising inhibitory effects and low toxicities, were further found to possess immune regulatory activities upon cross-linking of T cell receptor (TCR) and B cell receptor (BCR) on purified T and B cells, respectively.
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