期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 29, 期 12, 页码 -出版社
SPRINGER
DOI: 10.1007/s10856-018-6193-7
关键词
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资金
- National Natural Science Foundation of China [51672087]
- Science and Technology Program of Guangzhou City of China [201508020017]
- Fundamental Research Funds for the Central Universities
sThe inferior anti-washout property of injectable calcium phosphate cement (CPC) limits its wider application in clinic. In this study, the improvement of anti-washout performance of CPC by addition of konjac glucomannan or guar gum, which was dissolved in the CPC liquid, was first studied. The influence of KGM/GG blend with different mass ratios on the anti-washout property, compressive strength and in vitro cytocompatibility of CPC was estimated. The results revealed that small amount of KGM or GG could obviously enhance the anti-washout property of CPC. Moreover, the washout resistance efficiency of KGM/GG blend was better than KGM or GG alone. The addition of KGM/GG blend slightly shortened the final setting time of CPC. Although the introduction of KGM/GG blend reduced the compressive strength of CPC, the compressive strength still reached or surpassed that of human cancellous bone. The best KGM/GG mass ratio was 5:5, which was most efficient at not only reducing CPC disintegration, but also increasing compressive strength. The addition of KGM/GG blend obviously promoted the cells proliferation on the CPC. In short, the CPC modified by KGM/GG blend exhibited excellent anti-washout property, appropriate setting time, adequate compressive strength, and good cytocompatibility, and has the potential to be used in bone defect repair. Graphical Abstract The addition of KGM/ GG blend significantly improved the anti- washout property of CPC. The best KGM/ GG mass ratio was 5: 5, which was most efficient in reducing the CPC disintegration. [GRAPHICS] .
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