期刊
JOURNAL OF MAGNETIC RESONANCE
卷 297, 期 -, 页码 23-32出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2018.10.002
关键词
Dynamic nuclear polarization; Cryogenic magic angle spinning; Instrumentation; Transmission line probes; Electron decoupling
资金
- NSF-IDBR [CAREER DBI-1553577]
- NIH Director's New Innovator Award from the National Institutes of Health [DP2GM119131]
- Camille Dreyfus Teacher -Scholar Award
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [DP2GM119131] Funding Source: NIH RePORTER
Dynamic nuclear polarization (DNP) with cryogenic magic angle spinning (MAS) provides significant improvements in NMR sensitivity, yet presents unique technical challenges. Here we describe a custom cryostat and suite of NMR probes capable of manipulating nuclear spins with multi-resonant radiofrequency circuits, cryogenic spinning below 6 K, sample exchange, and microwave coupling for DNP. The corrugated waveguide and six transfer lines needed for DNP and cryogenic spinning functionality are coupled to the probe from the top of the magnet. Transfer lines are vacuum-jacketed and provide bearing and drive gas, variable temperature fluid, two exhaust pathways, and a sample ejection port. The cryostat thermally isolates the magnet bore, thereby protecting the magnet and increasing cryogen efficiency. This novel design supports cryogenic MAS-DNP performance over an array of probes without altering DNP functionality. We present three MAS probes (two supporting 3.2 mm rotors and one supporting 9.5 mm rotors) interfacing with the single cryostat. Mechanical details, transmission line radio frequency design, and performance of the cryostat and three probes are described. (C) 2018 Published by Elsevier Inc.
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