期刊
JOURNAL OF INVESTIGATIVE MEDICINE
卷 66, 期 8, 页码 1083-1087出版社
SAGE PUBLICATIONS LTD
DOI: 10.1136/jim-2018-000874
关键词
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资金
- Health Science Centre General Operating grant
- Research Manitoba New Investigator Award
- Mitacs Accelerate postdoctoral fellowship
- Natural Sciences and Engineering Council of Canada (NSERC)
- Cancer Research Society (CRS)
- Heart and Stroke Foundation of Canada
Patients with glioblastoma multiforme (GBM) have an average life expectancy of approximately 15 months. Recently, statins have emerged as a potential adjuvant cancer therapy due to their ability to inhibit cell proliferation and induce apoptosis in many types of cancer. The exact mechanisms that mediate the inhibitory actions of statins in cancer cells are largely unknown. The purpose of this proceeding paper is to discuss some of the known anticancer effects of statins, while focusing on GBM therapy that includes adjunct therapy of statins with chemotherapeutic agents.
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