期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 139, 期 4, 页码 769-778出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2018.10.032
关键词
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类别
资金
- American Skin Association
- Dermatology Foundation
- immunoSEQ Young Investigator Award
- National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health [AR061437, AR069114]
- Kawaja Vitiligo Research Initiative
- Vitiligo Research Foundation
- Dermatology Foundation Stiefel Scholar Award
- National Institutes of Health Training Grant [AI095213]
- National Institutes of Health Clinical and Translational Sciences Award [UL1TR000161]
Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model. We found that both Trm and Tcm sensed autoantigen in the skin long after stabilization of disease, producing IFN-gamma, CXCL9, and CXCL10. Blockade of Tcm recruitment to the skin with FTY720 or depletion of Tcm with low-dose Thy1.1 antibody reversed disease, indicating that Trm cooperate with Tcm to maintain disease. Taken together, our data provide characterization of skin memory T cells in vitiligo, demonstrate that Trm and Tcm work together during disease, and indicate that targeting their survival or function may provide novel, durable treatment options for patients.
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