期刊
JOURNAL OF INNATE IMMUNITY
卷 11, 期 2, 页码 111-124出版社
KARGER
DOI: 10.1159/000493719
关键词
Chorioallantoic membrane; Chick embryo; Innate immunity; Antimicrobial peptides; Avian beta-defensins; Toll-like receptors; Eggshell
类别
资金
- LE STUDIUM
- Natural Sciences and Engineering Research Council of Canada
The integrated innate immune features of the calcareous egg and its contents are a critical underpinning of the remarkable evolutionary success of the Aves clade. Beginning at the time of laying, the initial protective structures of the egg, i.e., the biomineralized eggshell, egg-white antimicrobial peptides, and vitelline membrane, are rapidly and dramatically altered during embryonic development. The embryo-generated extra-embryonic tissues (chorioallantoic/amniotic membranes, yolk sac, and associated chambers) are all critical to counteract degradation of primary egg defenses during development. With a focus on the chick embryo (Gallus gallus domesticus), this review describes the pro-gressive transformation of egg innate immunity by embryogenerated structures and mechanisms over the 21-day course of egg incubation, and also discusses the critical interplay between autonomous development and maternal anticipation. (c) 2018 The Author(s) Published by S. Karger AG, Basel.
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