期刊
JOURNAL OF INFECTIOUS DISEASES
卷 219, 期 9, 页码 1356-1363出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy675
关键词
Undernutrition; tuberculosis; nutrition disorders; body mass index; latent Mycobacterium tuberculosis infection
资金
- US Civilian Research and Development Foundation (CRDF) [USB-31150-XX-13]
- National Science Foundation [OISE-9531011]
- Government of India's Department of Biotechnology
- Indian Council of Medical Research
- National Institutes of Health, the National Institute of Allergy and Infectious Diseases
- Office of AIDS Research
- Warren Alpert Foundation
- Boston University School of Medicine
- Clinical and Translational Sciences Institute [1UL1TR001430]
- Providence/Boston Center for AIDS Research [P30AI042853]
- Boston University/Rutgers Tuberculosis Research Unit [U19AI111276]
Almost 800 million people are chronically undernourished worldwide, of whom 98% are in low- and middle-income countries where tuberculosis is endemic. In many tuberculosis-endemic countries, undernutrition is a driver of tuberculosis incidence and associated with a high population attributable fraction of tuberculosis and poor treatment outcomes. Data suggest that undernutrition impairs innate and adaptive immune responses needed to control Mycobacterium tuberculosis infection and may affect responses to live vaccines, such as BCG. Given its impact on tuberculosis, addressing undernutrition will be a vital component of the World Health Organization End TB strategy. This narrative review describes the effect of undernutrition on the immune response, vaccine response, and tuberculosis incidence, severity, and treatment outcomes.
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