期刊
JOURNAL OF INFECTIOUS DISEASES
卷 219, 期 10, 页码 1652-1661出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy700
关键词
influenza; obesity; T cells; memory; metabolism; weight loss
资金
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [R01-DK106090]
- Derfner Foundation
Background. Obesity is an independent risk factor for increased influenza mortality and is associated with impaired memory T-cell response, resulting in increased risk of infection. In this study, we investigated if weight loss would restore memory T-cell response to influenza. Methods. Male C57BL/6J mice were fed either low-fat or high-fat diet to induce obesity. Once obesity was established, all mice received primary infection with influenza X-31. Following a recovery period, we switched half of the obese group to a low-fat diet to induce weight loss. Fifteen weeks after diet switch, all mice were given a secondary infection with influenza PR8, and memory T-cell function and T-cell metabolism were measured. Results. Following secondary influenza infection, memory T-cell subsets in the lungs of obese mice were decreased compared to lean mice. At the same time, T cells from obese mice were found to have altered cellular metabolism, largely characterized by an increase in oxygen consumption. Neither impaired memory T-cell response nor altered T-cell metabolism was reversed with weight loss. Conclusion. Obesity-associated changes in T-cell metabolism are associated with impaired T-cell response to influenza, and are not reversed with weight loss.
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