期刊
JOURNAL OF INFECTION
卷 78, 期 3, 页码 208-214出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2018.11.007
关键词
Listeria; Listeriosis; Mortality; Risk factors; Non-pregnancy associated; Non-perinatal
资金
- Public health England
Listeriosis: is a foodborne illness that can result in septicaemia, Central Nervous System (CNS) disease, foetal loss and death in high risk patients. Objectives: To analyse the demographic trends, clinical features and treatment of non-perinatal listeriosis cases over a ten year period and identify mortality-associated risk factors. Methods: Reported laboratory-confirmed non-pregnancy associated cases of listeriosis between 2006 and 2015 in England were included and retrospectively analysed. Multivariate logistic regression analysis was performed to determine independent risk factors for mortality. Results: 1357/1683 reported cases met the inclusion criteria. Overall all-cause mortality was 28.7%; however, mortality rates declined from 42.1% to 20.2%. Septicaemia was the most common presentation 69.5%, followed by CNS involvement 22.4%. CNS presentations were significantly associated with age < 50 years, and septicaemia with older age. Age > 80 years (OR 3.32 95% CI 1.92-5.74), solid-organ malignancy (OR 3.42 95% CI 2.29-5.11), cardiovascular disease (OR 3.30 95% CI 1.64-6.63), liver disease (OR 4.61 95% CI 2.47-8.61), immunosuppression (OR 2.12 95% CI 1.40-3.21) and septicaemia (OR 1.60 95% CI 1.17-2.20) were identified as independent mortality risk factors. Conclusions: High risk groups identified in this study should be the priority focus of future public health strategies aimed at reducing listeriosis incidence and mortality. Crown Copyright (C) 2018 Published by Elsevier Ltd on behalf of The British Infection Association. All rights reserved.
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