期刊
JOURNAL OF IMMUNOLOGY
卷 202, 期 2, 页码 407-420出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1800261
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资金
- Ministry of Science and Technology of China [2014CB541903]
- National Natural Science Foundation of China [31871404, 31171348]
- Fundamental Research Funds for the Central Universities
Altered migration and immune responses of dendritic cells (DCs) lead to inflammatory and autoimmune diseases. Our studies demonstrated that beta-arrestin 2 deficiency promoted migration and cytokine production of mouse bone marrow-derived DCs. We further found that beta-arrestin 2 directly interacted with Zbtb46, a DC-specific transcription factor. What's more, our results suggested that the interaction between beta-arrestin 2 and Zbtb46 might negatively regulate DC migration. Using RNA sequencing, we indicated that genes CD74, NR4A1, and ZFP36 might be the target genes regulated by the interaction between beta-arrestin 2 and Zbtb46. Mice with selective deficiency of beta-arrestin 2 in DCs developed severer experimental autoimmune encephalomyelitis with more DC infiltration in the CNS and increased IL-6 in serum. In the systemic lupus erythematosus mice model, Arrb2(fl/fl) Itgax-cre(+) mice were prone to exacerbation of lupus nephritis with a higher level of IL-6 and DC accumulation. Taken together, our study identified beta-arrestin 2 as a new regulator of DC migration and immune properties, providing new insights into the mechanisms underlying the development of autoimmune disease.
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