期刊
JOURNAL OF GENERAL VIROLOGY
卷 100, 期 1, 页码 84-88出版社
MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.001188
关键词
atypical porcine pestivirus; congenital tremor; complete genome; novel genogroup E
资金
- 13th Five-Year Plan National Key Research and Development Program of PR China [2016YFD0500705]
- National Natural Science Foundation of PR China [31772766]
- Innovative Research Team Program of the Department of Education of Sichuan Province [13TD0057]
- Fundamental Research Funds for the Central Universities of Southwest Minzu University [2018HQZZ15]
Atypical porcine pestivirus (APPV) causes congenital tremor (CT) in piglets and has a wide geographical distribution. In this study, we evaluated APPV prevalence using 165 piglet sera from southwest China. Viral RNA was detectable by qRT-PCR in 43.6 % (17/39, 95 % CI 27.8-60.4%) of piglets with CT, while viral RNA was not detected in the sera of any healthy piglets. The seven complete APPV genomes were obtained from distinct farms and were 11 269-11 459 nucleotides in length. The genomes of the seven strains shared 82.8-98 % identity with the APPV reference strains. Phylogenetic analysis of the complete genomes as well as E2 and Nrpo sequences revealed that the seven APPVs clustered into two groups: four strains belonged to genogroups A and D and three strains belonged to a novel APPV genotype, tentatively called genogroup E. This study provides important insights into the epidemiological features and genetic diversity of APPV.
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