Evolving the Paradigm of Early Drain Removal Following Pancreatoduodenectomy

BackgroundRecent data illustrates improved outcomes when adhering to early drain removal following pancreatoduodenectomy (PD). This study aims to explore the potential benefits of expanding the timeframe for early drain removal.MethodsSix hundred forty PDs were originally managed by selective drain placement and early removal. Outcomes were reappraised in the framework of a novel proposal; intraoperative drains were omitted based on a low-risk profile (Fistula Risk Score 0-2), followed by drain removal at PODs 1, 3, and 5 if drain fluid amylase (DFA) fell below specific cutoffs based on optimized negative predictive values (NPV) for clinically relevant postoperative pancreatic fistula (CR-POPF). Characteristics of the remaining cohort with drains in situ on POD5 were examined using multivariable analysis (MVA).ResultsIntraoperative FRS would preclude drains from 230 (35.9%) negligible/low-risk cases with a cohort CR-POPF rate of 1.7%. Of the remaining patients, 30.5% would have drains removed on POD1 based on a DFA threshold of 300IU/L (NPV=98.4%), demonstrating a 1.6% CR-POPF rate. On POD3, drains could be removed in the residual cohort from 21.1% of patients with DFA 150IU/L (NPV=96.6%), reflecting a 3.4% CR-POPF rate. On POD5, a DFA threshold of 50IU/L (NPV=84%) identified 16.3% more patients whose drains could be removed. The remaining cohort (POD5 DFA >50IU/L), enriched for fistula development and reflecting just 18.4% of the original patients, displays a 61% CR-POPF rate. Among these patients on POD5, a DFA threshold >2000IU/L best predicted subsequent CR-POPF (PPV=89.5%), and MVA revealed a positive association between pancreatic cancer/pancreatitis (OR=4.37, p=0.022) and longer operations (OR=3.74, p=0.014) with CR-POPF development.ConclusionEarly drain removal is a dynamic concept and can be employed throughout the postoperative time course using conditional thresholds to better identify patients at risk for CR-POPF.