期刊
JOURNAL OF CROHNS & COLITIS
卷 13, 期 5, 页码 659-668出版社
OXFORD UNIV PRESS
DOI: 10.1093/ecco-jcc/jjy201
关键词
EMT; epithelial-to-mesenchymal transition; intestinal fibrosis; inflammatory bowel disease; Crohn's disease; ulcerative colitis; EndMT
资金
- Associazione Italiana Ricerca sul Cancro [AIRC]
- Cancer Prevention Research Institute of Texas [CPRIT]
Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation, which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition [EMT] represents an embryonic program relaunched during wound healing, fibrosis and cancer. Here we discuss the initial observations and the most recent findings highlighting the role of EMT in IBD-associated intestinal fibrosis and fistulae formation. In addition, we briefly review knowledge on the cognate process of endothelial-to-mesenchymal transition [EndMT]. Understanding EMT functionality and the molecular mechanisms underlying the activation of this mesenchymal programme will permit designing new therapeutic strategies to halt the fibrogenic response in the intestine.
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