期刊
JOURNAL OF CRITICAL CARE
卷 48, 期 -, 页码 445-450出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jcrc.2018.07.010
关键词
Venoarterial PCO2; Arteriovenous oxygen content difference; Central venous blood; Mixed venous blood; Hemoglobin
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina [PICT-2010-0495]
Purpose: Central venous minus arterial PCO2 to arterial minus central venous O(2 )content difference ratio (Pcv-aCO2/Ca-cvO2) has been proposed as a clinical surrogate for respiratory quotient. Our goal was to assess its interchangeability with mixed venous minus arterial PCO2 to arterial minus mixed venous O(2 )content difference ratio (Pmv-aCO2/Ca-mvO2). Materials and methods: This is a subanalysis of a previously published study. We studied 23 septic patients who had an indwelling Swan-Ganz catheter. The agreement between Pcv-aCO2/Ca-cvO2 and Pmv-aCO2/Ca-mvO2 was evaluated by Bland and Altman analysis. We also performed linear regression analysis with Pmv-aCO2/Ca-mvO2 as the dependent variable. Results: 95% limits of agreement between Pcv-aCO2/Ca-cvO2 and Pmv-aCO2/Ca-mvO2 were 1.48. Pmv-aCO2/Ca-mvO2 was significantly correlated with hemoglobin and lactate (R-2 = 0.48 and 0.31, respectively, P < 0.01 for both). Conclusions: In this study, Pcv-aCO2/Ca-cvO2 and Pmv-aCO2/Ca-mvO2 were not interchangeable. In addition, Pmv-aCO2/Ca-mvO2 is a composite variable, which depends on several determinants. Values of Pcv-aCO2/Ca-cvO2 should be cautiously interpreted in the assessment of critically ill patients. (C) 2018 Elsevier Inc. All rights reserved.
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