期刊
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
卷 47, 期 3, 页码 484-490出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jcms.2018.12.011
关键词
Dental implants; Osseointegration; Surface conditioning; Cold atmospheric plasma
资金
- UKSH-foundation (Kiel, Germany) [006_2015]
- CAMLOG-Foundation (Basel, Switzerland) [CF31601]
Purpose: Successful implant therapy is based on fast, safe, and predictable osseointegration. Several surface modifications have been introduced to improve the bone-to-implant interaction. This in vivo study evaluates the impact of plasma surface conditioning on early wound healing and osseointegration. Materials and methods: A total of 16 dental implants with a sand-blasted and acid-etched surface were conditioned with cold atmospheric plasma prior to insertion in the frontal bone of four miniature pigs. Sequential fluorescence labeling was administered to label bone metabolism, and after 8 weeks, bone blocks were harvested for radiological, histological, and histomorphometrical evaluation. Results: The plasma conditioning had no impact on the morphology of the implant surface. The bone-to-implant contact ratio was 90.4% and 86.5%, the interthread bone density 72.5% and 63.4%, and the periimplant bone density 60.5% and 61.1%, in the plasma conditioned group and control group, respectively. Concentric bands of fluorescence enrichment indicated a chronological and homogenous mineralization of newly formed bone. No unwanted periimplant side effects were detected. Conclusion: The increased parameters for osseointegration in this in vivo study merit further investigation in prospective clinical trials. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
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