Association between sensory nerve action potential and lumbar dorsal root ganglion area

Objective: To quantify the cross-sectional area (CSA) of lumbar dorsal root ganglion (DRG) by magnetic resonance imaging (MRI) and investigate the relationship between the cross-sectional area (CSA) of DRGs and sensory nerve action potentials (SNAP) amplitude in the lower extremities. Methods: Thirty-eight DRGs (20 L5 roots and 18 51 roots) in 10 adult subjects were reviewed retrospectively. The CSA of the DRG was calculated from MR images of the coronal plane. SNAP amplitudes of the superficial peroneal nerve and sural nerve were corresponded to L5 and S1-DRGs. Results: The mean CSA of DRGs was 66.6 +/- 13.7 mm(2) in L5-DRG and 79.5 +/- 14.3 mm(2) in S1-DRG. The means of SNAP amplitudes were 19.6 +/- 6.2 mu V in superficial peroneal nerves and 24.6 +/- 9.0 mu V in sural nerves. In multivariate regression analysis, the CSA of DRGs had a significant correlation with SNAP amplitude. Conclusion: The area of L5 and S1-DRGs may be positively correlated with SNAP amplitude. (C) 2018 Elsevier Ltd. All rights reserved.