期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1587, 期 -, 页码 111-118出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2018.12.013
关键词
Agaricus bisporus; Antibacterial drugs; Mushroom; UHPLC-MS/MS
资金
- KNOW (Leading National Research Centre) Scientific Consortium in Poland Healthy Animal - Safe Food, decision of Ministry of Science and Higher Education [05-1/KNOW2/2015]
A multi-residue method was developed for the determination of 45 antibacterial compounds in mushrooms - Agaricus bisporus. The method is based on liquid-liquid extraction with acetonitrile with addition of trichloroacetic acid and filtration through sodium sulphate, followed by the identification and quantification of the analyte residues by ultra-high performance liquid chromatography triple quadrupole tandem mass spectrometry (UHPLC-IVIS/MS). Satisfactory linearity was obtained for all compounds with regression coefficients greater than 0.99. The mean recoveries of antibacterial agents were in the range of 73% - 118%. Repeatability and intra-lab reproducibility were lower than 10% and 15%, respectively. The limit of detection ranged from 0.3-3.0 mu g kg(-1) and the limit of quantification was in the range of 1.0 - 10. 0 mu g kg(-1) depending on analyte. The proposed method can be successfully applied for the determination of antibiotics in commercially available mushrooms. (C) 2018 Elsevier B.V. All rights reserved.
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