期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 5, 页码 5588-5600出版社
WILEY
DOI: 10.1002/jcp.27384
关键词
biogenesis; cardiovascular disease; circular RNA; miRNA sponge
资金
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
Circular RNA (circRNA) are endogenous transcripts that display differential expression across species, developmental stages, and pathologies. Their lack of free ends confers increased stability when compared with linear transcripts, making them ideal candidates for future diagnostic biomarkers and therapeutic interventions. Increasing evidence has implicated circRNA in the pathogenesis of multiple cardiovascular diseases. In this paper, we summarize current understanding of circRNA biogenesis, properties, expression profiles, detection methods, functions, and their implication in cardiac pathologies including/ischemia reperfusion injury, myocardial infarction, cardiac senescence, cardiac fibrosis, cardiomyopathy, cardiac hypertrophy and heart failure, atherosclerosis, coronary artery disease, and aneurysm.
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