期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 7, 页码 10157-10165出版社
WILEY
DOI: 10.1002/jcp.27684
关键词
chemoresistance; CRC; lncRNA; microRNA; SCARNA2
资金
- National Natural Science Foundation of China [81702868]
- Tongji University [2016KJ061]
- Jiangxi Province Science Foundation for Youths [20171BAB215036]
- Youth Fund of Shanghai Xuhui District Science and Technology Commission [SHXH201630]
Long noncoding RNAs (lncRNAs) have been implicated in numerous physiological and pathological processes, including cancer development and progression. However, the role and molecular mechanism of lncRNAs in resistance to chemotherapy of colorectal cancer (CRC) remain enigmatic. Here, we found that lncRNA small Cajal body-specific RNA 2 (SCARNA2) is expressed higher in CRC tissues than in adjacent normal tissues, and a robust expression of SCARNA2 is correlated with a bad prognosis of CRC patients after surgery. SCARNA2 overexpression significantly promoted chemoresistance in CRC cells, and downregulation of SCARNA2 obviously inhibited chemoresistance in vitro. SCARNA2 promotes chemotherapy resistance via competitively binding miR-342-3p to facilitate epidermal growth factor receptor (EGFR) and B-cell lymphoma 2 (BCL2) expression in CRC cells. Together, our results reveal a novel pathway that SCARNA2 regulates CRC chemoresistance through targeting miR-342-3p-EGFR/BCL2 pathway, providing a promising therapeutic target for CRC.
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