期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 6, 页码 9105-9117出版社
WILEY
DOI: 10.1002/jcp.27587
关键词
breast cancer; lncRNA-CDC6; metastasis; miR-215; proliferation
资金
- Scientific Foundation of Qilu hospital [2016QLQN13]
- Natural Science Foundation of Shandong Province [ZR20172190450]
- National Natural Science Foundation of China [81272903, 81502285, 81672613]
- Key Research and Development Program of Shandong Province [2016GGE2775]
- Special Support Plan for National High Level Talents
- Shandong Science and Technology Development Plan [2016CYJS01A02]
- China Postdoctoral Science Foundation [2018M630787]
Rapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA-cell division cycle 6 (CDC6) in regulating proliferation and metastasis of breast cancer. Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. Functionally, the ectopic expression of lncRNA-CDC6 promoted proliferation via regulation of G1 phase checkpoint, and further promoting the migration capability. Moreover, lncRNA-CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA-215 (miR-215), which further regulating the expression of CDC6. Taken together, our results proved that lncRNA-CDC6 could function as ceRNA and promote the proliferation and metastasis of breast cancer cells, which provided a novel prognostic marker for breast cancers in clinic.
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