期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 120, 期 5, 页码 8521-8533出版社
WILEY
DOI: 10.1002/jcb.28140
关键词
6-phosphogluconate dehydrogenase; glucose-6-phosphate dehydrogenase; lifespan; nicotinamide adenine dinucleotide phosphate generation; redox homoeostasis; Saccharomyces cerevisiae
资金
- Narodowe Centrum Nauki [2017/01/X/NZ1/00153]
Intermediary metabolites have a crucial impact on basic cell functions. There is a relationship between cellular metabolism and redox balance. To maintain redox homoeostasis, the cooperation of both glutathione and nicotine adenine dinucleotides is necessary. Availability of nicotinamide adenine dinucleotide phosphate (NADPH) as a major electron donor is critical for many intracellular redox reactions. The activity of glucose-6-phosphate dehydrogenase (Zwf1p) and 6-phosphogluconate dehydrogenase (Gnd1p and Gnd2p) is responsible for NADPH formation in a pentose phosphate (PP) pathway. In this study, we examine the impact of redox homoeostasis on cellular physiology and proliferation. We have noted that the Delta zwf1 mutant lacking the rate-limiting enzyme of the PP pathway shows changes in the cellular redox status caused by disorders in NADPH generation. This leads to a decrease in reproductive potential but without affecting the total lifespan of the cell. The results presented in this paper show that nicotine adenine dinucleotides play a central role in cellular physiology.
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