期刊
AAPS PHARMSCITECH
卷 18, 期 6, 页码 1917-1924出版社
SPRINGER
DOI: 10.1208/s12249-016-0664-2
关键词
antifungal release; clotrimazole; co-extruded fiber; poly(caprolactone)
资金
- National Science Foundation (NSF) Science and Technology Center
- Center for Layered Polymeric Systems (CLiPS) [DMR-0423914]
- NSF [CMMI-1335276]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1335276] Funding Source: National Science Foundation
We report the successful implementation of a novel melt co-extrusion process to fabricate ca. 1 mu m diameter fibers of poly(caprolactone) (PCL) containing the antifungal compound clotrimazole in concentrations between 4 and 8 wt%. The process involves co-extrusion of a clotrimazole-loaded PCL along with poly(ethylene oxide) (PEO) as a co-feed, with subsequent removal of PEO to isolate PCL-clotrimazole fibers. In vitro tests of the clotrimazole-containing fibers against the fungus Aspergillus fumigatus, Candida albicans, and Trichophyton mentagrophytes strains demonstrated good antifungal activity which was maintained for more than 3 weeks. An in vivo study using a mouse model showed the lowest tissue fungal burden for PCL-clotrimazole when compared to a PCL-only patch and untreated controls. Comparative studies were conducted with clotrimazole-containing PCL fibers fabricated by electrospinning. Our data showed that the co-extruded, clotrimazole-containing fibers maintain activity for longer times vs. electrospun samples. This, coupled with the much higher throughput of the co-extrusion process vs. electrospinning, renders this new approach very attractive for the fabrication of drug-releasing polymer fibers.
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