期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 107, 期 4, 页码 1159-1169出版社
WILEY
DOI: 10.1002/jbm.b.34209
关键词
nanoporous contact lens; drug delivery; temperature-triggered drug release; sustained drug release; drug-eluting contact lens; bicontinuous microemulsion
资金
- Industrial Materials Fundamental Technology Development Program [10052981]
- Ministry of Trade, Industry and Energy of Korea
The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100-250 nm) that are interconnected via multiple nano-channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)-carried thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanogel (30-50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug-loading and release in silicon- or polyethylene oxide-microemulsion BMCLs under various conditions. Nanoporous BMCLs containing thermosensitive TM-laden nanogel were capable of potent body-temperature-triggered release of TM. Daily drug release was controllable according to the initial volume of drug-loaded (VDL) and loading method for sustained drug release, making them reduce drug-loss during transportation or storage. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1159-1169, 2019.
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