期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 106, 期 11, 页码 2881-2890出版社
WILEY
DOI: 10.1002/jbm.a.36477
关键词
nanoparticles; blood-brain barrier; cell-mediated transcytosis; polyanhydrides; mito-apocynin
资金
- US Army Medical Research and Materiel Command [W81XWH-11-1-0700]
- Iowa State University Nanovaccine Institute
- National Institute of Health [R01 MH081780, R01 MH094160, P01DA028555, R01 AG043530, P30 MH062261, R01 MH115860, R01 NS034249, R01 NS036126]
- National Science Foundation Graduate Research Fellowship Program [DGE1247194]
An urgent need to deliver therapeutics across the blood-brain barrier (BBB) underlies a paucity of effective therapies currently available for treatment of degenerative, infectious, traumatic, chemical, and metabolic disorders of the nervous system. With an eye toward achieving this goal, an in vitro BBB model was employed to simulate biodegradable polyanhydride nanoparticle-based drug delivery to the brain. Using a combination of confocal microscopy, flow cytometry, and high performance liquid chromatography, we examined the potential of polyanhydride nanoparticles containing the anti-oxidant, mito-apocynin, to be internalized and then transferred from monocytes to human brain microvascular endothelial cells. The efficacy of this nanoparticle-based delivery platform was demonstrated by neuronal protection against oxidative stress. Taken together, this polyanhydride nanoparticle-based delivery system holds promise for enhancing neuroprotection by facilitating drug transport across the BBB. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2881-2890, 2018.
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