期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 34, 期 1, 页码 16-24出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911518809110
关键词
Polyaniline; cytotoxicity; acute oral toxicity; histopathology
资金
- Natural Science Foundation of Ningxia [2018AAC03072]
- Ningxia High School first-class Disciplines (West China first-class Disciplines Basic Medical Sciences at Ningxia Medical University) [NXYLXK2017B07]
- Natural Science Foundation of Ningbo [2017A610269]
- National Natural Science Foundation of China [31260243]
To investigate the biocompatibility of polyaniline nanomaterials as the drug carrier, polyaniline nanospheres with high-molecular weight (Mw 48,000) and nanofibers with low-molecular weight (Mw 4000) were prepared and cytotoxicity, acute oral toxicity test, and histopathology examination were performed. Cytotoxicity test showed that both nanofibers and nanospheres were quite toxic to BV2 microglia cells at higher concentration and the former were more toxic than the latter. No clear sign of acute toxicity was found after oral administration. However, histopathology section demonstrated slight liver damage present when administrated polyaniline nanofibers with 100mg/mL. The results revealed that the higher of the molecular weight, the lower toxicity it had. Preparing polyaniline with higher molecular weight may be one of the methods to obtain polyaniline with good biocompatibility. The results gave a better understanding of biocompatibility of polyaniline nanomaterial and made it more practical in medical field.
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