期刊
JOURNAL OF ASTHMA
卷 56, 期 12, 页码 1257-1265出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02770903.2018.1536145
关键词
Asthma; airway epithelial cell; epithelial barrier dysfunction; airway inflammation; tight junction
资金
- NHLBI NIH HHS [T32 HL066988, F32 HL110718, R01 HL122424, F31 HL140795] Funding Source: Medline
- NIAID NIH HHS [T32 AI007285] Funding Source: Medline
- NIEHS NIH HHS [T32 ES007026, P30 ES001247] Funding Source: Medline
Objective: Airway epithelial barrier dysfunction is emerging as an important feature of asthma pathogenesis, but this is difficult to measure in individual subjects. We aimed to develop a noninvasive way to measure airway permeability in asthma. Methods: Healthy controls and subjects with mild asthma inhaled dry powder mannitol in a dose-escalating manner on two separate occasions, stopping at 155?mg or 315?mg. Serum mannitol levels were measured at baseline and then 30, 90, and 150?min after mannitol inhalation. Mannitol absorption was compared with measurements of airflow obstruction (FEV1) and airway inflammation (FeNO). Results: Serum mannitol levels increased in a time- and dose-dependent manner in both healthy control and subjects with asthma. There were no significant differences in mannitol absorption when comparing healthy controls and subjects with asthma. Mannitol absorption did not correlate with markers of airway obstruction or inflammation. Conclusions: Measuring serum concentrations of mannitol after inhalation challenge can potentially provide insights into airway barrier function in asthma.
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