期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 21, 期 8, 页码 742-753出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2018.1490273
关键词
Long non-coding RNA; ginsenoside Rh2; hepatocellular carcinoma; HepG2; gene expression profile
资金
- Science and Technology Program of Guangzhou [201607010015]
- Natural Science Foundation of Guangdong [2016A030313525]
Microarray expression profiles of lncRNAs and mRNAs were investigated in HepG2 cells treated with 20 mu g/ml ginsenoside Rh2 as well as in ginsenoside Rh2-untreated cells. Microarray analysis showed 618 upregulated lncRNAs and 161 downregulated lncRNAs in HepG2 cells treated with ginsenoside Rh2 compared with the control group. Moreover, three differentially expressed lncRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR). This may be beneficial to patients as an anti-cancer treatment and potentially provide novel targets for HCC (hepatocellular carcinoma) therapy. [GRAPHICS] .
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