期刊
JOURNAL OF ANTIBIOTICS
卷 72, 期 2, 页码 111-113出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/s41429-018-0110-7
关键词
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资金
- NSFC [81703388, 81741156]
- Shanghai Sailing Program [17YF1403700]
- Fundamental Research Funds for the Central Universities [222201714023, 22221818014]
- Talent Program of School of Biotechnology in East China University of Science and Technology
Curvulaide A (1), a new bicyclic polyketide, together with its known congener preussilide D, were produced by solid-state fermentation with Curvularia sp. IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data, high resolution electrospray ionization mass spectrometry (HRESIMS), experimental and calculated electronic circular dichroism (ECD) spectra. Curvulaide A (1) exhibited moderate anti-anaerobic bacteria activity against periodontal pathogen Porphyromonas gingivalis with the MIC value of 62.5 mu M, and showed moderate cytotoxicity against human hepatoma cell lines BEL7402/5-Fu with IC50 values of 12.46 mu M.
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