期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 66, 期 3, 页码 1223-1234出版社
IOS PRESS
DOI: 10.3233/JAD-180541
关键词
Alzheimer's disease; amyloid-beta; default mode network; resting state fMRI
资金
- institutional development award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health [5P20GM109025]
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd
- Fujirebio
- AbbVie
- BioClinica, Inc.
- Eisai Inc.
- Genentech, Inc.
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM109025] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG024904] Funding Source: NIH RePORTER
Lateralization of default mode network (DMN) functioning has been shown to change with age Similarly, lateralization of frontal lobe function has been shown to decline in age. The impact of amyloid pathology and the progression of Alzheimer's disease (AD) on resting state lateralization has not been investigated. Due to the preferential involvement of the left hemisphere in verbal tasks, there may be a benefit to higher levels of left-lateralization in the performance of verbal memory tasks. Here we compared functional lateralization of the anterior and posterior DMN between four groups of participants: amyloid negative (A beta-) and amyloid positive (A beta+) groups with normal cognition (NC), and A beta+ groups with mild cognitive impairment (A beta+MCI) or dementia (A beta+AD). Differences were evident between groups in posterior DMN; the A beta-NC group was more left-lateralized than both cognitively impaired A beta+ groups. There was no difference in anterior DMN. No differences in overall network connectivity between groups were observed, suggesting that the functional lateralization finding is not secondary to general changes in connectivity. Left-lateralization of both networks was associated with better verbal recall performance. Older subjects, overall, had less left functional lateralization of the anterior DMN.
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