期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 44, 页码 11531-11543出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b04014
关键词
anthocyanins; tissue bioavailability; health; animal studies; mechanism-of-action; phenolic compounds
资金
- Ministerio de Economia, Industria y Competitividad [AGL2016-76943-C2-2-R, AGL2016-76943-C2-1-R]
- Agencia Estatal de Investigacion (AEI) [AGL2016-76943-C2-2-R, AGL2016-76943-C2-1-R]
- European Regional Development Fund (ERDF) [AGL2016-76943-C2-2-R, AGL2016-76943-C2-1-R]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant [713679]
- Universitat Rovira i Virgili (URV)
- Generalitat de Catalunya [SLT002/16/00239]
- Generalitat de Catalunya, Spain [2017 SGR 522]
Anthocyanins (ACNs) are promising health-enhancing phenolic compounds. We focus on ACN animal tissue bioavailability to provide an evidentiary link between tissue ACNs and their associated health properties. We performed a systematic review of electronic libraries; 279 results were retrieved, and 13 publications met inclusion criteria. Extracted information included animal model employed, administration route, doses, analysis method, and ACN concentration values in tissues. Total ACN concentrations were detected in mice kidney (2.17 x 10(5) pmol/g), liver (1.73 x 10(5) pmol/g), heart (3.6 x 10(3) pmol/g), and lung (1.16 x 10(5) pmol/g); and in pig brain (6.08 x 10(3) pmol/g). ACNs showed a predominance of parent ACNs in long-term experiments versus an ACN metabolite predominance in short-term experiments. ACNs detected in animal tissues, such as cyanidin-3-glucoside, suggest it may have an important role in human health. This information could be useful to determine proper ACN-intake biomarkers in biological samples in futures studies.
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