期刊
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
卷 36, 期 12, 页码 2901-2906出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/bkcs.10601
关键词
Nonsteroidal anti-inflammatory drugs; Dispersive liquid-liquid microextraction; High Performance Liquid Chromatography
资金
- Kyonggi University Research Grant
A simple, effective, and environmentally friendly sample preparation method was developed by using dispersive liquid-liquid microextraction prior to high-performance liquid chromatography analysis for the extraction/ concentration and assay of nonsteroidal anti-inflammatory drugs (NSAIDs), including indoprofen, ketoprofen, naproxen, diclofenac, ibuprofen, mefenamic acid, and tolfenamic acid, from an aqueous sample. The extraction conditions were optimized with respect to several experimental parameters (dispersive solvent, extraction solvent, pH, salt additive, and concentration) for the simultaneous extraction and analysis of NSAIDs by the response surface methodology based on the central composite design method. The limit of detection and limit of quantitation of the spiked sample were in the concentration range of 0.65-1.3 and 2.2-4.4 mu g/L, respectively. The accuracy and precision in the working range were 85-106% and 0.5-10.4% (relative standard deviation), respectively. The linear equations for quantitative analysis were in the concentration range of 0.5-5.0 mu g/L with correlation coefficients (R-2 = 0.9990-0.9996).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据