期刊
INVESTIGATIONAL NEW DRUGS
卷 37, 期 4, 页码 722-730出版社
SPRINGER
DOI: 10.1007/s10637-018-0714-6
关键词
Phase 1; Tarextumab; Notch inhibition
资金
- OncoMed Pharmaceuticals
Purpose This Phase I trial evaluated the maximum tolerated dose, safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of tarextumab (OMP-5948), a novel cross-reactive antibody which binds and selectively inhibits signaling via both Notch2 and Notch3, in adult patients with advanced malignancies. Methods Standard 3+3 design with tarextumab 0.5, 1, 2.5, or 5mg/kg weekly, or 5, 7.5, or 10mg/kg every other week, or 7.5mg every 3weeks. Dose-limiting toxicities (DLT) were assessed during the first 28days. Results Forty-two patients received tarextumab (21 weekly, 15 every other week, 6 every three weeks). 2/6 subjects at the 5mg/kg weekly dose, 2/3 at 10mg/kg every other week, and 0/6 at 7.5mg/kg every three weeks had a DLT. The maximum tolerated dose (MTD) was 2.5mg/kg weekly, and 7.5mg/kg on the every other and every three week schedules. Gastrointestinal (GI) toxicity was the most common adverse event with diarrhea (81%), fatigue (48%), nausea (45%), anorexia (38%), and vomiting (38%) and abdominal pain and constipation (24% each). Biomarker analysis showed regulation of stem cell and Notch gene signaling. Conclusion Tarextumab was generally well-tolerated at doses <2.5mg weekly and 7.5mg/kg every other and every third week. Diarrhea was dose-limiting above these levels, but relatively easily managed at lower doses. Inhibition of Notch pathway signaling was demonstrated at these doses. ClinicalTrials.gov Identifier: NCT01277146.
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