期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 68, 期 14, 页码 844-849出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2018.1517346
关键词
Biodegradable; carboxymethyl chitosan; drug release; embolization microspheres; oxidated alginate
Embolization microspheres were prepared through two steps. The microspheres demonstrated regular sphericity with a main size distribution in the range of 100 mu m similar to 270 mu m. An anticancer drug doxorubicin could be loaded into the microspheres with high loading rates from 21% to 32% due to physical and ionic interaction of carboxyl groups in the microspheres and amino groups in doxorubicin. The drug could be controlled released at different pH conditions. The blank microspheres were biodegradable, non-cytotoxic, and the drug-eluting embolization microspheres could be potentially applied as embolic agents in interventional therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据