期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 69, 期 3, 页码 158-172出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2018.1552860
关键词
Prostate cancer; polymeric micelles; sorafenib; pluronic F127-lithocholic acid conjugate; LNCaP cells
资金
- Research Vice Chancellery of Isfahan University of Medical Sciences
In present study, sorafenib loaded nanomicelles were prepared with synthesized pluronic F127 - lithocholic acid by film hydration method. The optimized micelles were spherical showing particle size of 319.36 nm, zeta potential of -11.96 mV, encapsulation efficiency of 87.31%, loading efficiency of 14.87% and release efficiency of 30.1%. Sorafenib loaded nanomicelles showed negligible hemolysis activity on RBC, indicating excellent hemocompatibility of pluronic F127 - lithocholic acid. The drug free nanomicelles showed no cytotoxicity against L929 cells by using MTT assay. However, micellar sorafenib showed more anti-proliferation effect on LNCaP and DU145 cells as compared with free sorafenib.
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