期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 69, 期 4, 页码 211-221出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2018.1552865
关键词
Crosslinking; cyclodextrin citrate; drug release; modeling; silk fibroin
A novel beta-cyclodextrin-grafted silk fibroin (SF) nanofibers was successfully fabricated. The morphology and diameter of the electrospun nanofibers were characterized. FE-SEM images showed that the morphology and diameter of the nanofibers were mainly affected by weight ratio of the blend. FTIR, H-1-NMR, DSC and TGA confirmed the crosslinking reaction between beta-cyclodextrin and SF. The release rate of Ciprofloxacin was measured and observed that the SF-g-CD nanofibrous mat provided slower release of the entrapped drug when compared with SF nanofibrous mat. A mathematical analysis of the drug release data suggested that the Higuchi model was the best fitted model.
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