期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 68, 期 13, 页码 788-795出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2018.1506984
关键词
Sialorrhea; scopolamine; natural rubber latex; sustained release; biomaterial
资金
- CAPES
- CNPq [470261/2012-9]
- FAPESP [2014/17526-8, 2011/17411-8]
- PADC [2018/01-I]
Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.
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