期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms19113403
关键词
evodiamine; alkaloid; antiproliferative effect; structural modification
资金
- Key Laboratory of Quality Control of TCM of Liaoning Province [17-137-1-00]
- Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University
- China Postdoctoral Science Foundation [2017M621161, 2018T110462]
- General Scientific Research Projects of Department of Education in Liaoning Province [2017LQN05]
Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive multitargeting antiproliferative activity. Its high content in the natural source ensures its adequate supply on the market and guarantees further medicinal study. To the best of our knowledge, there is no systematic review about the antiproliferative effects of evodiamine derivatives. Therefore, in this article the review of the antiproliferative activities of evodiamine will be updated. More importantly, the antiproliferative activities of structurally modified new analogues of evodiamine will be summarized for the first time.
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