期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms19103022
关键词
rice bran; -tocotrienol; inflammation; MAPKs; PPARs; RAW264; 7
资金
- Project 2011 Collaborative Innovation Center of Hunan province [448]
- Natural Science Foundation of Hunan Province [2018JJ2672, 2017JJ3528]
- Key Project of the Education Department of Hunan province [16A228]
- Special Fund for Agro-scientific Research in the Public Interest of China [201303071-2-1]
- Key Research and Develop Plan Project of Hunan Province [2017SK2190]
- Science and Technology Innovation Platform and Talent Project of Hunan Province [2017TP1021]
-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, -tocotrienol was isolated and purified from rice bran. The anti-inflammatory effect and mechanism of -tocotrienol against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264.7 cells were investigated. Results showed that -tocotrienol significantly inhibited LPS-stimulated nitric oxide (NO) and proinflammatory cytokine (TNF-, IFN-, IL-1 and IL-6) production and blocked the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular regulated protein kinases 1/2 (ERK1/2). -Tocotrienol repressed the transcriptional activations and translocations of nuclear factor-kappa B (NF-B) and activator protein-1 (AP-1), which were closely related with downregulated cytokine expressions. Meanwhile, -tocotrienol also affected the PPAR signal pathway and exerted an anti-inflammatory effect. Taken together, our data showed that -tocotrienol inhibited inflammation via mitogen-activated protein kinase (MAPK) and peroxisome proliferator-activated receptor (PPAR) signalings in LPS-stimulated macrophages.
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