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Tetrahydrobiopterin, superoxide, and vascular dysfunction
Jeannette Vasquez-Vivar
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Tyrosine Nitration of PA700 Activates the 26S Proteasome to Induce Endothelial Dysfunction in Mice With Angiotensin II-Induced Hypertension
Jian Xu et al.
HYPERTENSION (2009)
Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans
Robert D. Brook et al.
HYPERTENSION (2009)
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
Jae Hyung Kim et al.
JOURNAL OF APPLIED PHYSIOLOGY (2009)
Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status INSIGHTS FROM CELLS WITH TET-REGULATED GTP CYCLOHYDROLASE I EXPRESSION
Mark J. Crabtree et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase
Annemarieke E. Loot et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis
Antonella Di Cesare et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)
Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis
D. D. Balci et al.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2009)
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases
Peter D. Gluckman et al.
NATURE REVIEWS ENDOCRINOLOGY (2009)
Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design
Hans-Henrik Parving et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)
Homocysteine decreases platelet NO level via protein kinase C activation
Maria Grazia Signorello et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2009)
Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes
Irina A. Ionova et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction
Thomas Muenzel et al.
ANNALS OF MEDICINE (2008)
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
Eberhard Schulz et al.
ANTIOXIDANTS & REDOX SIGNALING (2008)
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
Philip Wenzel et al.
ATHEROSCLEROSIS (2008)
Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction
Daniela Fraccarollo et al.
CIRCULATION (2008)
Epigenetic regulation of vascular endothelial gene expression
Charles C. Matouk et al.
CIRCULATION RESEARCH (2008)
Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes
A. Riad et al.
DIABETOLOGIA (2008)
AT(1)-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats
Philip Wenzel et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCε signaling axis in pulmonary artery smooth muscle cells
Rakesh Rathore et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Adiponectin is a better predictor of endothelial function of the coronary artery than HOMA-R, body mass index, immunoreactive insulin, or triglycerides
Hideki Okui et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2008)
C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling
Uma Singh et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2007)
4-hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation
Jennifer Whitsett et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Role of the T cell in the genesis of angiotensin II-induced hypertension and vascular dysfunction
Tomasz J. Guzik et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Proteasome-dependent degradation of guanosine 5′-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
Jian Xu et al.
CIRCULATION (2007)
NXY-059 for the treatment of acute ischemic stroke
Ashfaq Shuaib et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Heme oxygenase-1 -: A novel key player in the development of tolerance in response to organic nitrates
Philip Wenzel et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
The L-arginine paradox:: Importance of the L-arginine/asymmetrical dimethylarginine ratio
Stefanie M. Bode-Boeger et al.
PHARMACOLOGY & THERAPEUTICS (2007)
Irbesartan for the treatment of hypertension in patients with the metabolic syndrome:: A sub analysis of the Treat to Target post authorization survey.: Prospective observational, two armed study in 14,200 patients
Ulrich Kintscher et al.
CARDIOVASCULAR DIABETOLOGY (2007)
A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis
Taral N. Patel et al.
EUROPEAN HEART JOURNAL (2007)
Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?
Michael R. Dashwood et al.
JOURNAL OF VASCULAR RESEARCH (2007)
Phosphodiesterase inhibitors
V Boswell-Smith et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Outcomes by gender in the African-American heart failure trial
Anne L. Taylor et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Mycophenolate mofetil treatment improves hypertension in patients with psoriasis and rheumatoid arthritis
Jose Herrera et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats
Matthias Oelze et al.
HYPERTENSION (2006)
Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy
Ken-ichiro Sasaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels - Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
Charalambos Antoniades et al.
CIRCULATION (2006)
Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats
Huige Li et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
NADPH oxidases in cardiovascular health and disease
Alison C. Cave et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Endothelial nitric oxide synthase in vascular disease -: From marvel to menace
U Förstermann et al.
CIRCULATION (2006)
The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults
S Ashfaq et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Pathogenesis and treatment of kidney disease and hypertension - The determinants of endothelial dysfunction in CKD: Oxidative stress and asymmetric dimethylarginine
MI Yilmaz et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2006)
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
Oleg V. Evgenov et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis
NL Mills et al.
CIRCULATION (2005)
Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo - Insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression
JK Bendall et al.
CIRCULATION RESEARCH (2005)
Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease -: Results from the AtheroGene study
R Schnabel et al.
CIRCULATION RESEARCH (2005)
Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent protein kinase
T Münzel et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Inhibition of cortisol production with metyrapone prevents mental stress-induced endothelial dysfunction and baroreflex impairment
AJM Broadley et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)
The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code
JE Fish et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
K Chalupsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase
YH Gan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Oxidative activation of protein kinase Cγ through the C1 domain -: Effects on gap junctions
DB Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase
T Wallerath et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2005)
Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
NJ Alp et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study
A Rosengren et al.
LANCET (2004)
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
S Yusuf et al.
LANCET (2004)
The cell-specific expression of endothelial nitric-oxide synthase - A role for DNA methylation
Y Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Combination of isosorbide dinitrate and hydralazine in blacks with heart failure
AL Taylor et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Endothelial function, inflammation, and prognosis in cardiovascular disease
MA Gonzalez et al.
AMERICAN JOURNAL OF MEDICINE (2003)
Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production
MI Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Oxidative stress and cardiovascular injury - Part II: Animal and human studies
KK Griendling et al.
CIRCULATION (2003)
Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease
S Blankenberg et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Oxidative stress and cardiovascular injury - Part I: Basic mechanisms and in vivo monitoring of ROS
KK Griendling et al.
CIRCULATION (2003)
Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495
H Lenasi et al.
CARDIOVASCULAR RESEARCH (2003)
Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease
B Pitt et al.
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2003)
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols - Implications for uncoupling endothelial nitric-oxide synthase
N Kuzkaya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Regulation of endothelial nitric oxide synthase by protein kinase C
M Matsubara et al.
JOURNAL OF BIOCHEMISTRY (2003)
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
U Landmesser et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Intensive blood pressure control reduces the risk of cardiovascular events in patients with peripheral arterial disease and type 2 diabetes
PS Mehler et al.
CIRCULATION (2003)
ADMA and oxidative stress
K Sydow et al.
ATHEROSCLEROSIS SUPPLEMENTS (2003)
Association of asymmetric dimethylarginine and endothelial dysfunction
RH Boger
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2003)
Role of p47phox in vascular oxidative stress and hypertension caused by angiotensin II
U Landmesser et al.
HYPERTENSION (2002)
Functional and analytical evidence for scavenging of oxygen radicals by L-arginine
A Lass et al.
MOLECULAR PHARMACOLOGY (2002)
Mechanisms of increased vascular superoxide production in human diabetes mellitus Role of NAD(P)H oxidase and endothelial nitric oxide synthase
TJ Guzik et al.
CIRCULATION (2002)
Oxidation and nitrosation in the nitrogen monoxide/superoxide system
A Daiber et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric Oxide/cGMP signaling
H Mollnau et al.
CIRCULATION RESEARCH (2002)
Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate
S Oberle et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
T Heitzer et al.
CIRCULATION (2001)
Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance - A human in vivo study
T Gori et al.
CIRCULATION (2001)
Nebivolol reverses endothelial dysfunction in essential hypertension - A randomized, double-blind, crossover study
N Tzemos et al.
CIRCULATION (2001)
Prognostic significance of endothelial dysfunction in hypertensive patients
F Perticone et al.
CIRCULATION (2001)
Phosphorylation of Thr495 regulates Ca2+/calmodulin-dependent endothelial nitric oxide synthase activity
I Fleming et al.
CIRCULATION RESEARCH (2001)
Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study
KT Khaw et al.
LANCET (2001)
Mental stress induces transient endothelial dysfunction in humans
L Ghiadoni et al.
CIRCULATION (2000)
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
T Heitzer et al.
DIABETOLOGIA (2000)
Nebivolol:: A third-generation β-blocker that augments vascular nitric oxide release endothelial β2-adrenergic receptor-mediated nitric oxide production
MAW Broeders et al.
CIRCULATION (2000)
Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
V Schächinger et al.
CIRCULATION (2000)
Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers -: Evidence for a dysfunctional nitric oxide synthase
T Heitzer et al.
CIRCULATION RESEARCH (2000)