期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 284, 期 -, 页码 99-104出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2018.10.083
关键词
Arrhythmogenic right ventricular cardiomyopathy; Cardiac magnetic resonance imaging; F-18-fluorodeoxyglucose; Positron emission tomography; Myocarditis
资金
- European Society of Cardiology [R-2017-071]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable heart muscle disease that causes sudden cardiac death in the young. Inflammatory myocardial infiltrates have been described at autopsy and on biopsy, but there are few data on the presence of myocarditis in living patients with ARVC using non-invasive imaging techniques. FDG-PET is a validated technique for detecting myocardial inflammation in clinically suspectedmyocarditis. We aimed to determine the prevalence of myocardial inflammation in patients with ARVC using F-18-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods and results: We performed a retrospective analysis of a single centre cohort of patients with ARVC referred for FDG-PET scans between 2012 and 2017 for investigation of symptoms or suspected device infection. Sixteen patients (12 male; age 42 +/- 13 years) with a definite diagnosis of ARVC were identified. Seven had positive FDG-PET scans, two of whom had cardiac sarcoidosis on endomyocardial biopsy. Of the remaining five, two carried pathogenic desmoplakin mutations. FDG uptake was found in the left ventricular myocardium in all cases. One patient also had right ventricular uptake. Conclusion: In this exploratory study, we show that some patients with ARVC have evidence for myocardial inflammation on FDG-PET, suggesting that myocarditis plays a role in disease pathogenesis. (c) 2018 Elsevier B.V. All rights reserved.
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