期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 127, 期 -, 页码 476-485出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.01.067
关键词
Antioxidant; Hepatoprotective activities; Modified polysaccharides; Coprinus comatus
资金
- Mushroom Technology System of Shandong Province [SDAIT-07-05]
A modified polysaccharide named MPCC from Coprinus comatus (MPCC) was obtained by the snailase hydrolysis. And the hepatoprotective effects on alcohol-induced liver injury and preliminary structure features were investigated. For in vivo hepatoprotective abilities, MPCC significantly attenuated the hepatic and serum lipid levels, obviously enhanced antioxidant enzyme activities, markedly improved alcohol metabolism system and inflammatory response, and mitigated alcohol-induced liver injury histopathologically, providing references for the exploitation of MPCC as functional foods or natural drugs against the alcohol-induced liver injury. Additionally, MPCC containing fucose (Fuc), ribose (Rib), arabinose (Ara), xylose (Xyl), mannose (Man), galactose (Gal) and glucose (Glu) with the a alpha- and beta-configuration in a percentage composition of 0.91%, 0.71%, 0.45%, 1.60%, 2.04%, 4.41% and 89.88% via gas chromatography (GC), Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR) analysis. (C) 2019 Published by Elsevier B.V.
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