期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 121, 期 -, 页码 407-414出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.09.197
关键词
Sargassum pallidum; Polysaccharides; Sulfation modification; Antioxidant; Hypoglycemic activity
资金
- National Natural Science Foundation of China [31801542]
- Natural Science Foundation of Guangdong Province [2018A030310383]
- National International Science and Technology Cooperation Base for Tropical Health Food [2017D01005]
- Fundamental Research Funds for the Central Universities of China [2017BQ100]
- Science & Technology Planning Project of Nansha, Guangzhou [2016GJ001]
- 111 Project [B17018]
The aim of this study was to investigate the effect of sulfated modification on the in vitro antioxidant and hypoglycemic activities of Sargassum pallidum polysaccharides (SPP). Three sulfated derivatives (S-SPP1-4, S-SPP1-6 and S-SPP1-8) were prepared using chlorosulfonic acid-pyridine method under different reaction conditions. Physicochemical characterization indicated that sulfated modification had successfully occurred. The degrees of substitution (DS) of S-SPP1-4, S-SPP1-6 and S-SPP1-8 were determined to be ranging from 0.85 to 1.19. Sulfated modification resulted in some changes in chemical component, molecular weight and monosaccharide composition of SPP. Among these sulfated polysaccharides, S-SPP1-4 exhibited the best DPPH and ABTS radical scavenging activities, while S-SPP1-8 exhibited the best alpha-glucosidase inhibitory activity and promoting-effect on glucose consumption in insulin resistant (IR)-HepG2 cells. Furthermore, all the sulfated derivatives exhibited better hypoglycemic ability than native SPP. These results suggest that appropriately sulfated modification could enhance the antioxidant and hypoglycemic activities of S. pallidum polysaccharides, which might be used as an alternative derivative of natural antioxidant and hypoglycemic agent. (C) 2018 Elsevier B.V. All rights reserved.
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