期刊
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
卷 100, 期 9-12, 页码 3045-3054出版社
SPRINGER LONDON LTD
DOI: 10.1007/s00170-018-2899-4
关键词
Divergence electrospinning; 3D nanofiber scaffold; Tissue engineering; Dimensional design
资金
- Foundation of the Whitacre College of Engineering
- Office of Vice President for Research at Texas Tech University
Latest bioinspired approaches in tissue engineering focus on the creation of biomaterials with micro- and nanoscale topographical features. Various additive manufacturing techniques have been applied for scaffold fabrication; however, creating three dimensional (3D) nanofiber structure within a scaffold remains to be challenging. This paper presented an innovative divergence electrospinning strategy to fabricate 3D polycaprolactone (PCL) scaffolds comprised of uniaxially aligned nanofibers. The effects of collector geometry on the nanofiber structure were characterized by polynomial regression analysis. The length-to-width ratio and inclination angle of the collector were found to be critical to nanofiber distribution within the 3D scaffold. The nanofiber orientation was consistent with the direction of electric field vectors between the two bevels of the collector. After a continuous culturing for 7days, fibroblast cells were uniaxially organized within the 3D scaffolds, closely resembling the fibrous structure in musculoskeletal tissues. This study provided a novel approach to biomimetic native tissue microstructures and showed a great potential as a future fabrication additive manufacturing platform for tissue engineering.
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