期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 65, 期 -, 页码 279-283出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2018.09.039
关键词
Breast cancer; Chemotherapy; T cells; Immune function
资金
- 12th Five Year science and technology research project of Jilin Province Educational Department [179]
Objective: Breast cancer and its surgical treatment and chemotherapy have great impact on the immune system. This study aimed to monitor the various T cells in breast cancer patients and evaluate the immune functions. Methods: Blood samples were collected from 249 breast cancer patients at the following time points: 1-3 days preoperative, postoperative (before the chemotherapy), after 3 chemotherapy cycles, and after 6 chemotherapy cycles. The percentages of the CD3(+), CD4(+), CD8(+), CD45RA(+), and CD45RO(+) T cells were measured using flow cytometry. Another 200 healthy women were used as control. Results: Patients with stage breast cancer had significantly lower percentages of CD3+, CD4+, CD8+, CD45RA(+), and CD28(+) T cells in comparison with normal control and those with stage I breast cancer (P < 0.05). The percentages of CD45RO(+) T cells and CD4(+)CD25(+) (Treg) cells were significantly higher in stage II/III malignancies versus stage I, and was significantly higher in stage I malignancies versus the normal control (P < 0.05). Breast cancer patients had significantly lower percentages of CD3(+) and CD4(+) T cells in comparison with the normal control (P < 0.05). The preoperative percentages of CD3+ and CD4(+) T cells were significantly reduced after 3 cycles and after 6 cycles of chemotherapy (P < 0.05). In patients with stage malignancies, there was a higher percentage of CD45RO(+) T cells than CD45RA(+) T cells, which was reversed after surgery. After 6 chemotherapy cycles, the percentage of Treg cells was significantly reduced in comparison with that before the chemotherapy in the patients with stage II/III malignancies. Conclusions: Patients with breast cancer had significantly suppressed immune functions. Surgical removal of the tumor may improve the immune functions. Chemotherapy significantly reduced the percentages of CD3(+) and CD4(+) T cells.
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