期刊
IMMUNITY
卷 50, 期 1, 页码 253-+出版社
CELL PRESS
DOI: 10.1016/j.immuni.2018.11.004
关键词
-
类别
资金
- Simons Foundation/SFARI [346197]
- Silvio O. Conte Center (NIH) [P50MH112491]
- Stanley Center for Psychiatric Research at the Broad Institute
- Helen Hay Whitney Fellowship
- Lundbeck Foundation International Postdoc Fellowships
- [3214]
Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. Here, we analyzed the RNA expression patterns of more than 76,000 individual microglia in mice during development, in old age, and after brain injury. Our analysis uncovered at least nine transcriptionally distinct microglial states, which expressed unique sets of genes and were localized in the brain using specific markers. The greatest microglial heterogeneity was found at young ages; however, several states-including chemokine-enriched inflammatory microglia-persisted throughout the lifespan or increased in the aged brain. Multiple reactive microglial subtypes were also found following demyelinating injury in mice, at least one of which was also found in human multiple sclerosis lesions. These distinct microglia signatures can be used to better understand microglia function and to identify and manipulate specific subpopulations in health and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据