期刊
HUMAN PATHOLOGY
卷 86, 期 -, 页码 155-162出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2018.10.041
关键词
Ki-67; Paragangliomas; PD-L1; Pheochromocytomas; RNAscope
类别
资金
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine [2017-I2M-1-001, 2017-I2M-2-001]
- National Key Research and Development program of China: The cluster construction of human genetic resource Bio-bank in north China [2016YFC1201703]
The immunosuppressive effect of the programmed death (PD)-1/PD-L1 pathway plays an important role in the treatment of a variety of tumors, such as lung and breast cancer, but there is little literature about PD-1/PD-L1 in pheochromocytomas/paragangliomas (PCCs/PGLs). We explored the relationship of PD-L1 and malignant behavior in 77 cases of PCC/PGL using immunohistochemistry (IHC) to assess protein expression and RNAscope to detect mRNA expression in 20 cases. The IHC data showed that 59.74% of the PCCs/PGLs expressed PD-L1, and the extent of expression was highly correlated with Ki-67 (P = .019) and hypertension (P = .013) but not with age, sex, tumor size, capsular invasion, tumor necrosis, relapse/distant metastasis, secretion of noradrenaline/adrenaline/dopamine, or diabetes mellitus. In addition, we found an excellent correlation of PD-L1 mRNA and protein expression with a k coefficient of 0.828, and further stratification of the IHC and RNAscope findings showed high consistency (Pearson coefficient 0.753). The correlation of PD-L1 and Ki-67 indicated that PD-L1 could be considered a malignant proliferation biomarker for PCCs/PGLs, which would be a putative biomarker for anti-PD-L1 therapies. (C) 2018 Elsevier Inc. All rights reserved.
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