期刊
HUMAN BRAIN MAPPING
卷 40, 期 6, 页码 1750-1759出版社
WILEY
DOI: 10.1002/hbm.24487
关键词
bipolar disorder; emotional faces; fMRI; polygenic risk score; telomere length
资金
- European Union's Horizon 2020 Research and Innovation Programme [658195]
- Medical Research Council (MRC) [MRN014863/1]
- NARSAD 2014 Young Investigator Award [22471]
- NARSAD Young Investigator Grant [60373, YI 60373]
- Psychiatry Research Trust Grant [92]
- European Union [658195]
- Medical Research Council [MRN014863/1]
- Department of Health
- South London and Maudsley NHS Foundation Trust
- King's College London
- National Institute for Health Research
- MRC [MR/N014863/1] Funding Source: UKRI
- Marie Curie Actions (MSCA) [658195] Funding Source: Marie Curie Actions (MSCA)
Shorter telomere length (TL) has been associated with the development of mood disorders as well as abnormalities in brain morphology. However, so far, no studies have considered the role TL may have on brain function during tasks relevant to mood disorders. In this study, we examine the relationship between TL and functional brain activation and connectivity, while participants (n = 112) perform a functional magnetic resonance imaging (fMRI) facial affect recognition task. Additionally, because variation in TL has a substantial genetic component we calculated polygenic risk scores for TL to test if they predict face-related functional brain activation. First, our results showed that TL was positively associated with increased activation in the amygdala and cuneus, as well as increased connectivity from posterior regions of the face network to the ventral prefrontal cortex. Second, polygenic risk scores for TL show a positive association with medial prefrontal cortex activation. The data support the view that TL and genetic loading for shorter telomeres, influence the function of brain regions known to be involved in emotional processing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据