期刊
HORMONE RESEARCH IN PAEDIATRICS
卷 91, 期 2, 页码 137-151出版社
KARGER
DOI: 10.1159/000494809
关键词
Acute lymphoblastic leukemia; Hematopoietic stem cell transplantation; Osteonecrosis; Fractures; Radiotherapy; Chemotherapy; Osteochondroma; Retinoids
资金
- NIH [K07 CA166177]
- University of Ottawa Research Chair in Pediatric Bone Health, CHEO Departments of Surgeries and Pediatrics
- Canadian Institutes for Health Research
Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors. (c) 2018 S. Karger AG, Basel
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