4.5 Article

Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer

出版社

WILEY
DOI: 10.1002/hed.25563

关键词

cancer biomarker; cancer diagnostics; cell-free DNA; circulating tumor DNA; liquid biopsy

资金

  1. National Cancer Institute [R01CA208599]
  2. National Institutes of Health [1UL1TR001430]
  3. National Center for Advancing Translational Sciences [1UL1TR001430]
  4. Assar Gabrielssons Research Foundation
  5. Johan Jansson Foundation for Cancer Research
  6. Knut and Alice Wallenberg Foundation
  7. University of Gothenburg, Sweden
  8. Swedish government
  9. ALF-agreement [716321]
  10. Swedish Cancer Society [2016-438]
  11. Swedish Research Council [2017-01392]
  12. Swedish Childhood Cancer Foundation [2017-0043]
  13. Wilhelm and Martina Lundgren Foundation for Scientific Research
  14. VINNOVA
  15. Wallenberg Centre for molecular and translational medicine

向作者/读者索取更多资源

Background Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck cancer. Methods Patients diagnosed with head and neck squamous cell carcinoma were recruited into the study protocol. Tumors were sequenced to identify patient-specific mutations. Mutations were then identified in plasma circulating tumor DNA from pre-treatment blood samples and longitudinally during standard follow-up. Circulating tumor DNA status during follow-up was correlated to disease recurrence. Results Samples were taken from eight patients. Tumor mutations were verified in seven patients. Baseline circulating tumor DNA was positive in six patients. Recurrence occurred in four patients, two of whom had detectable circulating tumor DNA prior to recurrence. Conclusion Circulating tumor DNA is a potential tool for disease and recurrence monitoring following curative therapy in head and neck cancer, allowing for better prognostication, and/or modification of treatment strategies.

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