期刊
GLIA
卷 66, 期 12, 页码 2550-2562出版社
WILEY
DOI: 10.1002/glia.23510
关键词
Alzheimer's disease (AD); human subjects; microglial activation; neuroinflammation; pathogenesis
资金
- Deutsche Forschungsgemeinschaft [CRC 1052]
- Florida Department of Health [8AZ19]
Sporadic Alzheimer's disease (AD) is marked by a lengthy preclinical phase during which patients are nonsymptomatic but show pathology in variable manifestations. Whether or not neuroinflammation occurs in such nondemented individuals is unknown. We evaluated the medial temporal lobe of 66 nondemented subjects, aged 42-93, in terms of tau pathology, A beta deposition, and microglial activation. We show that 100% of subjects had neurofibrillary degeneration (NFD), 35% had A beta deposits, and 8% revealed microglial activation in individuals where early amyloid formation was apparent by Congo Red staining. Amyloid-induced neuroinflammatory clusters of Iba1, CD68, and ferritin-positive microglia were evident in the immediate vicinity of aggregated A beta. Microglia in the adjacent neuropil were nonactivated. Thus, neuroinflammation in AD represents a highly localized phagocyte reaction, essentially a foreign body response, geared toward removal of insoluble A beta. Because clustered microglia in some amyloid plaques were dystrophic and ferritin-positive, we hypothesize that these cells were exhausted by their attempts to remove the aggregated, insoluble A beta. Our findings show that the sequence of pathologic events in AD begins with tau pathology, followed by A beta deposition, and then by microglial activation. Because only 8% of our subjects revealed all three hallmark pathologic features, we propose that these nondemented individuals were near the threshold of transitioning from nonsymptomatic to symptomatic disease. The onset of neuroinflammation in AD may thus represent a tipping point in AD pathogenesis. Our study suggests that the role of microglia in AD pathogenesis entails primarily the attempted removal of potentially toxic, extracellular material.
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